Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland.

ABSTRACT:

Background

Tumor necrosis factor (TNF) inhibitors have improved treatment of ulcerative colitis (UC), but loss of response remains a frequent problem. The anti-TNF agent, golimumab, was approved in Switzerland for the treatment of UC in 2014. This study aims to summarize the experience of golimumab in a real-world setting in Switzerland.

Methods

We analyzed real-world data from 1769 UC patients from the Swiss Inflammatory Bowel Disease Cohort (SIBDC) study and performed a chart review of golimumab-treated patients. We extracted the partial Mayo score at t₀ (baseline), t₁ (2-16 weeks), t₂ (17-35 weeks), and t₃ (36-89 weeks). The primary endpoint was clinical response at t₁, defined as marked improvement in partial Mayo sc

SUBMITTER: Perrig K 

PROVIDER: S-EPMC8832575 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature