Cellular diversity and gene expression profiles in the male and female brain of Aedes aegypti.

ABSTRACT:

Background

Aedes aegypti is a medically-important mosquito vector that transmits arboviruses including yellow fever, dengue, chikungunya, and Zika viruses to humans. The mosquito exhibits typical sexually dimorphic behaviors such as courtship, mating, host seeking, bloodfeeding, and oviposition. All these behaviors are mainly regulated by the brain; however, little is known about the function and neuron composition of the mosquito brain. In this study, we generated an initial atlas of the adult male and female brain of Ae. aegypti using 10xGenomics based single-nucleus RNA sequencing.

Results

We identified 35 brain cell clusters in male and female brains, and 15 of those clusters were assigned to known cell types. Identified cell types include glia (astrocytes), Kenyon cells

SUBMITTER: Cui Y 

PROVIDER: S-EPMC8832747 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature