Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.

ABSTRACT:

Background

The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear.

Methods

Leveraging summary statistics of large-scale GWAS(s) conducted in European-ancestry populations on body mass index (adult BMI, N_female=434,794; childhood BMI, N=39,620), waist-to-hip ratio (WHR, N_female=381,152), WHR adjusted for BMI (WHR_adjBMI, N_female=379,501), and PCOS (N_case=10,074, N_control=103,164), we performed a large-scale genome-wide cross-trait analysis to quantify overall and local genetic correlation, to identify shared loci, and to infer causal relationship.

Results

We found positive genetic correlations between

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8832782 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature