Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial.

ABSTRACT:

Rationale

The long-acting β₂-agonist/long-acting muscarinic antagonist combination indacaterol/glycopyrronium (IND/GLY) elicits bronchodilation, improves symptoms, and reduces exacerbations in COPD. Magnetic resonance imaging (MRI) of the lung with hyperpolarized gas and gadolinium contrast enhancement enables assessment of whole lung functional responses to IND/GLY.

Objectives

The primary objective was assessment of effect of IND/GLY on global ventilated lung volume (%VV) versus placebo in COPD. Lung function, regional ventilation and perfusion in response to IND/GLY were also measured.

Methods

This double-blind, randomized, placebo-controlled, crossover study assessed %VV and pulmonary perfusion in patients with moderate-to-severe COPD after 8 days of onc

SUBMITTER: Singh D 

PROVIDER: S-EPMC8832861 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature