Indoor wood combustion, carcinogenic exposure and esophageal cancer in southwest Kenya.

ABSTRACT:

Background

Exposure to polycyclic aromatic hydrocarbons (PAHs) is a risk factor for esophageal squamous cell carcinoma (ESCC) in high-incidence areas of China, Iran and Brazil, but PAH assessments have not been conducted in East Africa, another ESCC hot spot.

Objective

To evaluate demographic or lifestyle factors associated with the PAH biomarker concentrations in the study population, and whether PAH metabolite concentrations showed any associations with esophageal precancerous lesions.

Methods

We recruited a community-based sample of 289 asymptomatic adults from a rural area of Kenya and performed Lugol's chromoendoscopy to detect esophageal squamous dysplasia (ESD); participants completed a questionnaire and provided a spot urine specimen. We analyzed urine for sev

SUBMITTER: Mwachiro MM 

PROVIDER: S-EPMC8832867 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature