Switch to Efavirenz Attenuates Lipoatrophy in Girls With Perinatal HIV.

ABSTRACT:

Objectives

Children with HIV (CHIV) have lifetime exposure to antiretrovirals (ART); therefore, optimizing their regimens to have the least impact on fat redistribution is a priority.

Methods

This is a cross-sectional study of 219 perinatally infected CHIV and 219 HIV-uninfected controls from similar socioeconomic backgrounds in Johannesburg, South Africa. We compared total body and regional fat distribution in CHIV on suppressive ART regimens with controls and, among CHIV, between ritonavir-boosted lopinavir (LPV/r)-based and efavirenz (EFV)-based regimens.

Results

The mean age of the 219 uninfected children (45% girls) and the 219 CHIV (48% girls) was 7.0 and 6.4 years, respectively. CHIV had lower adjusted total body fat (P = 0.005) and lower percentage fat at the

SUBMITTER: Su J 

PROVIDER: S-EPMC8832869 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature