Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women.

ABSTRACT:

Objective

There are many hereditary breast cancer patients in China, and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives. However, the magnitude of breast cancer risks related to multiple breast cancer susceptibility genes are largely unknown in Chinese women.

Methods

We screened pathogenic variants in 15 established or potential breast cancer susceptibility genes from 8,067 consecutive Chinese female breast cancer patients and 13,129 Chinese cancer-free female controls. These breast cancer patients were unselected for age at diagnosis or family history.

Results

We found that pathogenic variants in TP53 [odds ratio (OR): 16.9, 95% confidence interval (CI): 5.2-55.2]; BRCA2 (OR: 10.4, 95% CI: 7.6-1

SUBMITTER: Fu F 

PROVIDER: S-EPMC8832954 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature