Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial.

ABSTRACT:

Background and purpose

The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke.

Methods

We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed.

Results

We enrolled 173 patients with a mean a

SUBMITTER: Bu N 

PROVIDER: S-EPMC8832974 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature