40-Hz auditory stimulation for intracranial interictal activity: A pilot study.

ABSTRACT:

Objectives

To study the effects of auditory stimuli on interictal epileptiform discharge (IED) rates evident with intracranial monitoring.

Materials and methods

Eight subjects undergoing intracranial EEG monitoring for refractory epilepsy participated in this study. Auditory stimuli consisted of a 40-Hz tone, a 440-Hz tone modulated by a 40-Hz sinusoid, Mozart's Sonata for Two Pianos in D Major (K448), and K448 modulated by a 40-Hz sinusoid (modK448). Subjects were stratified into high- and low-IED rate groups defined by baseline IED rates. Subject-level analyses identified individual responses to auditory stimuli, discerned specific brain regions with significant reductions in IED rates, and examined the influence auditory stimuli had on whole-brain sigma power (12-16 Hz).<

SUBMITTER: Quon RJ 

PROVIDER: S-EPMC8832987 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature