A new signature based on alternative polyadenylation for prognostic prediction and therapeutic responses in low-grade glioma.

ABSTRACT:

Background

Evidence from research supports the significant role of alternative polyadenylation (APA) in the development of cancer. The aim of this study is to explore the prognostic and therapeutic value of APA events for patients with low-grade gliomas (LGG).

Methods

The gene expression and APA profiles of patients with low-grade gliomas were obtained from The Cancer Genome Atlas database. All patients were sorted randomly into training and test sets. The prognostic-associated events of alternative splicing were screened by univariate Cox regression. Subsequently, Least Absolute Shrinkage and Selection Operator and multivariate Cox analysis were performed to construct a prognostic signature. The patients were sorted into the high and low-risk groups based on their median ri

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8833112 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature