Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats.

ABSTRACT: Using animal models to study the underlying mechanisms of aging will create a critical foundation from which to develop new interventions for aging-related brain disorders. Aging-related reorganization of the brain network has been described for the human brain based on functional, metabolic and structural connectivity. However, alterations in the brain metabolic network of aging rats remain unknown. Here, we submitted young and aged rats to [18F]fluorodeoxyglucose with positron emission tomography (18F-FDG PET) and constructed brain metabolic networks. The topological properties were detected, and the network robustness against random failures and targeted attacks was analyzed for age-group comparison. Compared with young rats, aged rats showed reduced betweenness centrality (BC) i

SUBMITTER: Xue X 

PROVIDER: S-EPMC8833125 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature