A novel pyroptosis-related signature predicts prognosis and response to treatment in breast carcinoma.

ABSTRACT:

Background

Pyroptosis is a new form of programmed cell death (PCD), also known as cellular inflammatory necrosis. Its discovery has resulted in a novel approach to the progression and medication resistance of breast cancer (BC). However, there is still a significant gap in the investigation of pyroptosis-related genes in BC.

Methods

The mRNA expression profiles and clinical data of BC patients were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Then, using the TCGA cohort, we created a predictive multigene signature including pyroptosis-related genes and verified it using the two GEO cohorts. A pyroptosis-related gene signature was created by combining several bioinformatics and statistical methodologies to predict patient progn

SUBMITTER: Yu H 

PROVIDER: S-EPMC8833126 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature