Scripted spot removal in PBS proton therapy planning.

ABSTRACT:

Background

It is well known in proton therapy that the relative biological effectiveness (RBE) is not constant across the entire Bragg peak, with higher RBE at the distal end of the Bragg peak due to higher linear energy transfer (LET). Treatment planning systems are moving toward LET optimization to mitigate this potentially higher biological impact at a track end. However, using a simple script, proton users can begin to simulate this process by deleting spots from critical structures during optimization. In most cases, nominal target coverage and plan robustness remain satisfactory.

Methods

In our clinic, we developed a script that allows the user to delete spots in all organs at risk (OARs) of interest for one or more treatment beams. The purpose of this script is to pot

SUBMITTER: Hedrick SG 

PROVIDER: S-EPMC8833280 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature