State-dependent signatures of anti-N-methyl-d-aspartate receptor encephalitis.

ABSTRACT: Traditional static functional connectivity analyses have shown distinct functional network alterations in patients with anti-N-methyl-d-aspartate receptor encephalitis. Here, we use a dynamic functional connectivity approach that increases the temporal resolution of connectivity analyses from minutes to seconds. We hereby explore the spatiotemporal variability of large-scale brain network activity in anti-N-methyl-d-aspartate receptor encephalitis and assess the discriminatory power of functional brain states in a supervised classification approach. We included resting-state functional magnetic resonance imaging data from 57 patients and 61 controls to extract four discrete connectivity states and assess state-wise group differences in functional connectivity, dwell time, tra

SUBMITTER: von Schwanenflug N 

PROVIDER: S-EPMC8833311 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature