Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer.

ABSTRACT: Obesity is characterized by an excessive fat mass accumulation associated with multiple disorders, including impaired glucose homeostasis, altered adipokine levels, and hyperlipidemia. Despite clear associations between tumor progression and obesity, the effects of these disorders on tumor metabolism remain largely unknown. Thus, we studied the metabolic differences between tumors of obese and lean mice in murine models of triple-negative breast cancer (E0771 and PY8819). For this purpose, a real-time hyperpolarized 1-¹³C-pyruvate-to-lactate conversion was studied before and after glucose administration in fasting mice. This work was completed by U-¹³C glucose tracing experiments using nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry (MS). E

SUBMITTER: Yelek C 

PROVIDER: S-EPMC8833372 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature