Epigenetic Approaches to Overcome Fluoropyrimidines Resistance in Solid Tumors.

ABSTRACT: Although fluoropyrimidines were introduced as anticancer agents over 60 years ago, they are still the backbone of many combination chemotherapy regimens for the treatment of solid cancers. Like other chemotherapeutic agents, the therapeutic efficacy of fluoropyrimidines can be affected by drug resistance and severe toxicities; thus, novel therapeutic approaches are required to potentiate their efficacy and overcome drug resistance. In the last 20 years, the deregulation of epigenetic mechanisms has been shown to contribute to cancer hallmarks. Histone modifications play an important role in directing the transcriptional machinery and therefore represent interesting druggable targets. In this review, we focused on histone deacetylase inhibitors (HDACis) that can increase antitumor efficacy

SUBMITTER: Grumetti L 

PROVIDER: S-EPMC8833539 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature