Exercise against cocaine sensitization in mice: a [¹⁸F]fallypride micro-PET study.

ABSTRACT: Wheel-running exercise in laboratory rodents (animal model useful to study the neurobiology of aerobic exercise) decreases behavioural markers of vulnerability to addictive properties of various drugs of abuse including cocaine. However, neurobiological mechanisms underpinning this protective effect are far from fully characterized. Here, 28-day-old female C57BL/6J mice were housed with (n = 48) or without (n = 48) a running wheel for 6 weeks before being tested for acute locomotor responsiveness and initiation of locomotor sensitization to intraperitoneal injections of 8 mg/kg cocaine. The long-term expression of sensitization took place 3 weeks after the last session. On the day after, all mice underwent a micro-PET imaging session with [¹⁸F]fallypride radiotrace

SUBMITTER: Becker G 

PROVIDER: S-EPMC8833578 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature