The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer.

ABSTRACT: DNA methylation is an essential covalent modification that is required for growth and development. Once considered to be a relatively stable epigenetic mark, many studies have established that DNA methylation is dynamic. The 5-methylcytosine (5-mC) mark can be removed through active DNA demethylation in which 5-mC is converted to an unmodified cytosine through an oxidative pathway coupled to base excision repair (BER). The BER enzyme Thymine DNA Glycosylase (TDG) plays a key role in active DNA demethylation by excising intermediates of 5-mC generated by this process. TDG acts as a key player in transcriptional regulation through its interactions with various nuclear receptors and transcription factors, in addition to its involvement in classical BER and active DNA demethylation, which serv

SUBMITTER: Onabote O 

PROVIDER: S-EPMC8833622 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature