Effects of Leptin, Growth Hormone and Photoperiod on Pituitary SOCS-3 Expression in Sheep.

ABSTRACT: This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, and day length on the suppressor of cytokine signaling-3 (SOCS-3) mRNA levels in the adenohypophyses of sheep. The study consisted of two experiments. The first experiment was conducted during long (LD) and short (SD) days. Within-season and replicate sheep were centrally infused with Ringer-Locke buffer or leptin three times at 60-min intervals at the beginning of experiments. The second experiment involved adenohypophyses collected from sheep that were euthanized in May or November. Pituitary explants were treated with medium alone (Control) or medium with leptin or GH at different concentrations and incubated for various times. The results of the first experiment indicated GH c

SUBMITTER: Zieba DA 

PROVIDER: S-EPMC8833742 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature