Single-Cell Sequencing: Current Applications in Precision Onco-Genomics and Cancer Therapeutics.

ABSTRACT: Single-cell sequencing encompasses a variety of technologies that evaluate cells at the genomic, transcriptomic, epigenomic, and proteomic levels. Each of these levels can be split into additional techniques that enable specific and optimized sequencing for a specialized purpose. At the transcriptomic level, single-cell sequencing has been used to understand immune-malignant cell networks, as well as differences between primary versus metastatic tumors. At the genomic and epigenomic levels, single-cell sequencing technology has been used to study genetic mutations involved in tumor evolution or the reprogramming of regulatory elements present in metastasized disease, respectively. Lastly, at the proteomic level, single-cell sequencing has been used to identify biomarkers important for pred

SUBMITTER: Mustachio LM 

PROVIDER: S-EPMC8833749 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature