Evaluating Iodine-125 DNA Damage Benchmarks of Monte Carlo DNA Damage Models.

ABSTRACT: A wide range of Monte Carlo models have been applied to predict yields of DNA damage based on nanoscale track structure calculations. While often similar on the macroscopic scale, these models frequently employ different assumptions which lead to significant differences in nanoscale dose deposition. However, the impact of these differences on key biological readouts remains unclear. A major challenge in this area is the lack of robust datasets which can be used to benchmark models, due to a lack of resolution at the base pair level required to deeply test nanoscale dose deposition. Studies investigating the distribution of strand breakage in short DNA strands following the decay of incorporated 125I offer one of the few benchmarks for model predictions on this scale. In this work, we have

SUBMITTER: Thompson SJ 

PROVIDER: S-EPMC8833774 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature