Blood Circulating Non-Coding RNAs for the Clinical Management of Triple-Negative Breast Cancer.

ABSTRACT: Triple negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, and is related to unfavorable prognosis and limited treatment strategies. Currently, there is a lack of reliable biomarkers allowing for the clinical management of TNBC. This is probably caused by a complex molecular background, leading to the development and establishment of a unique tumor phenotype. Recent studies have reported non-coding RNAs (ncRNAs) not only as the most promising class of molecular agents with a high applicability to manage human cancers, including TNBC, but also as robust and non-invasive biomarkers that are able to be monitored in blood circulation, with the application of liquid biopsy. There is a lack of papers discussing the role of blood-circulating ncRNAs as diagnostic

SUBMITTER: Powrozek T 

PROVIDER: S-EPMC8833777 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature