Biopsy and Margins Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases.

ABSTRACT:

Background

Thermal ablation is a definitive local treatment for selected colorectal liver metastases (CLM) that can be ablated with adequate margins. A critical limitation has been local tumor progression (LTP).

Methods

This prospective, single-group, phase 2 study enrolled patients with CLM < 5 cm in maximum diameter, at a tertiary cancer center between November 2009 and February 2019. Biopsy of the ablation zone center and margin was performed immediately after ablation. Viable tumor in tissue biopsy and ablation margins < 5 mm were assessed as predictors of 12-month LTP.

Results

We enrolled 107 patients with 182 CLMs. Mean tumor size was 2.0 (range, 0.6-4.6) cm. Microwave ablation was used in 51% and radiofrequency ablation in 49% of tumors. The 12- and 24-month cu

SUBMITTER: Vasiniotis Kamarinos N 

PROVIDER: S-EPMC8833800 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature