An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.

ABSTRACT:

Background and objectives

Ischemic events, such as ischemic heart disease and stroke, are the number one cause of death globally. Ischemia prevents blood, carrying essential nutrients and oxygen, from reaching tissues, leading to cell and tissue death, and eventual organ failure. While humans are relatively intolerant to ischemic events, other species, such as marine mammals, have evolved a unique tolerance to chronic ischemia/reperfusion during apneic diving. To identify possible molecular features of an increased tolerance for apnea, we examined changes in gene expression in breath-holding dolphins.

Methodology

Here, we capitalized on the adaptations possesed by bottlenose dolphins (Tursiops truncatus) for diving as a comparative model of ischemic stress and hypoxia

SUBMITTER: Blawas AM 

PROVIDER: S-EPMC8833867 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature