Disparities in Lung Cancer: miRNA Isoform Characterization in Lung Adenocarcinoma.

ABSTRACT: Despite the development of targeted therapeutics, immunotherapy, and strategies for early detection, lung cancer carries a high mortality. Further, significant racial disparities in outcomes exist for which the molecular drivers have yet to be fully elucidated. The growing field of Epitranscriptomics has introduced a new layer of complexity to the molecular pathogenesis of cancer. RNA modifications can occur in coding and non-coding RNAs, such as miRNAs, possibly altering their gene regulatory function. The potential role for such modifications as clinically informative biomarkers remains largely unknown. Here, we concurrently profiled canonical miRNAs, shifted isomiRs (templated and non-templated), and miRNAs with single-point modification events (RNA and DNA) in White American (W) and Bl

SUBMITTER: Distefano R 

PROVIDER: S-EPMC8833952 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature