Dataset Information

Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen α_S1-Casein Content in Goat Mammary Epithelial Cells.

ABSTRACT: α_S1-Casein (encoded by the CSN1S1 gene) is associated with food allergy more than other milk protein components. Milk allergy caused by α_S1-casein is derived from cow milk, goat milk and other ruminant milk. However, little is known about the transcription regulation of α_S1-casein synthesis in dairy goats. This study aimed to investigate the regulatory roles of signal transducer and activator of transcription 5 (STAT5) on α_S1-casein in goat mammary epithelial cells (GMEC). Deletion analysis showed that the core promoter region of CSN1S1 was located at -110 to -18 bp upstream of transcription start site, which contained two putative STAT5 binding sites (gamma-interferon activation site, GAS). Overexpression of STAT5a gene upre

SUBMITTER: Song N

PROVIDER: S-EPMC8834060 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Dataset Information

Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen α_S1-Casein Content in Goat Mammary Epithelial Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen αS1-Casein Content in Goat Mammary Epithelial Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen α_S1-Casein Content in Goat Mammary Epithelial Cells.