Propofol-induced Unresponsiveness Is Associated with a Brain Network Phase Transition.

ABSTRACT:

Background

The wakeful brain can easily access and coordinate a large repertoire of different states-dynamics suggestive of "criticality." Anesthesia causes loss of criticality at the level of electroencephalogram waveforms, but the criticality of brain network connectivity is less well studied. The authors hypothesized that propofol anesthesia is associated with abrupt and divergent changes in brain network connectivity for different frequencies and time scales-characteristic of a phase transition, a signature of loss of criticality.

Methods

As part of a previously reported study, 16 volunteers were given propofol in slowly increasing brain concentrations, and their behavioral responsiveness was assessed. The network dynamics from 31-channel electroencephalogram data were c

SUBMITTER: Pullon RM 

PROVIDER: S-EPMC8834166 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature