Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models.

ABSTRACT: The survival rate among children with relapsed tumors remains poor, due to tumor heterogeneity, lack of directly actionable tumor drivers and multidrug resistance. Novel personalized medicine approaches tailored to each tumor are urgently needed to improve cancer treatment. Current pediatric precision oncology platforms, such as the INFORM (INdividualized Therapy FOr Relapsed Malignancies in Childhood) study, reveal that molecular profiling of tumor tissue identifies targets associated with clinical benefit in a subgroup of patients only and should be complemented with functional drug testing. In such an approach, patient-derived tumor cells are exposed to a library of approved oncological drugs in a physiological setting, e.g., in the form of animal avatars injected with patient tumor cel

SUBMITTER: Gatzweiler C 

PROVIDER: S-EPMC8834194 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature