Metabolic Alterations in a Drosophila Model of Parkinson's Disease Based on DJ-1 Deficiency.

ABSTRACT: Parkinson's disease (PD) is the second-most common neurodegenerative disorder, whose physiopathology is still unclear. Moreover, there is an urgent need to discover new biomarkers and therapeutic targets to facilitate its diagnosis and treatment. Previous studies performed in PD models and samples from PD patients already demonstrated that metabolic alterations are associated with this disease. In this context, the aim of this study is to provide a better understanding of metabolic disturbances underlying PD pathogenesis. To achieve this goal, we used a Drosophila PD model based on inactivation of the DJ-1β gene (ortholog of human DJ-1). Metabolomic analyses were performed in 1-day-old and 15-day-old DJ-1β mutants and control flies using ¹H nuclear ma

SUBMITTER: Solana-Manrique C 

PROVIDER: S-EPMC8834223 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature