Harnessing the Potential of NK Cell-Based Immunotherapies against Multiple Myeloma.

ABSTRACT: Natural killer (NK) cell-based therapies have emerged as promising anticancer treatments due to their potency as cytolytic effectors and synergy with concurrent treatments. Multiple myeloma (MM) is an aggressive B-cell malignancy that, despite development of novel therapeutic agents, remains incurable with a high rate of relapse. In MM, the inhospitable tumor microenvironment prevents host NK cells from exerting their cytolytic function. The development of NK cell immunotherapy works to overcome this altered immune landscape and can be classified in two major groups based on the origin of the cell: autologous or allogeneic. In this review, we compare the treatments in each group, such as autologous chimeric antigen receptor (CAR) NKs and allogeneic off-the-shelf NK cell infusions, and thei

SUBMITTER: Reina-Ortiz C 

PROVIDER: S-EPMC8834301 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature