Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20.

ABSTRACT:

Introduction

Haploinsufficiency of A20 (HA20) is a form of inborn errors of immunity (IEI). IEIs are genetically occurring diseases, some of which cause intestinal dysbiosis. Due to the dysregulation of regulatory T cells (Tregs) observed in patients with HA20, gut dysbiosis was associated with Tregs in intestinal lamina propria.

Methods

Stool samples were obtained from 16 patients with HA20 and 15 of their family members. Infant samples and/or samples with recent antibiotics use were excluded; hence, 26 samples from 13 patients and 13 family members were analyzed. The 16S sequencing process was conducted to assess the microbial composition of samples. Combined with clinical information, the relationship between the microbiome and the disease activity was statistically analy

SUBMITTER: Toyofuku E 

PROVIDER: S-EPMC8834539 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature