Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity.

ABSTRACT: The leptin receptor (LepR) acts as a signaling nexus for the regulation of glucose uptake and obesity, among other metabolic responses. The functional role of LepR under leptin-deficient conditions remains unclear. This study reports that epiregulin (EREG) governed glucose uptake in vitro and in vivo in Lep^ob mice by activating LepR under leptin-deficient conditions. Single and long-term treatment with EREG effectively rescued glucose intolerance in comparative insulin and EREG tolerance tests in Lep^ob mice. The immunoprecipitation study revealed binding between EREG and LepR in adipose tissue of Lep^ob mice. EREG/LepR regulated glucose uptake without changes in obesity in Lep^ob mice via mechanisms, including ERK activa

SUBMITTER: Song NJ 

PROVIDER: S-EPMC8834548 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature