Environmental and Circadian Regulation Combine to Shape the Rhythmic Selenoproteome.

ABSTRACT: The circadian clock orchestrates an organism's endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet's light/dark cycle on the generation of reactive oxygen species (ROS) and attain homeostasis. Selenoproteins are an important class of redox-related enzymes that have a selenocysteine residue in the active site. This study reports functional understanding of how environmental and endogenous circadian rhythms integrate to shape the selenoproteome in a model eukaryotic cell. We mined quantitative proteomic data for the 24 selenoproteins of the picoeukaryote Ostreococcus tauri across time series, under environmentally rhythmic entrained conditions of light/dark (LD) cycles, compared to c

SUBMITTER: Kay H 

PROVIDER: S-EPMC8834552 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature