Ontology highlight
ABSTRACT:
SUBMITTER: Nunes M
PROVIDER: S-EPMC8834752 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Nunes Mariana M Pacheco Francisca F Coelho Ricardo R Leitão Dina D Ricardo Sara S David Leonor L
International journal of molecular sciences 20220118 3
Mesothelin (MSLN) overexpression (OE) is a frequent finding in ovarian carcinomas and increases cell survival and tumor aggressiveness. Since cancer stem cells (CSCs) contribute to pathogenesis, chemoresistance and malignant behavior in ovarian cancer (OC), we hypothesized that MSLN expression could be creating a favorable environment that nurtures CSCs. In this study, we analyzed the expression of MSLN and CSC markers SOX2 and ALDH1 by immunohistochemistry (IHC) in different model systems: prim ...[more]