Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans.

ABSTRACT: To understand how pathology-induced changes in contractile protein isoforms modulate cardiac muscle function, it is necessary to quantify the temporal-mechanical properties of contractions that occur under various conditions. Pathological responses are much easier to study in animal model systems than in humans, but extrapolation between species presents numerous challenges. Employing computational approaches can help elucidate relationships that are difficult to test experimentally by translating the observations from rats and mice, as model organisms, to the human heart. Here, we use the spatially explicit MUSICO platform to model twitch contractions from rodent and human trabeculae collected in a single laboratory. This approach allowed us to identify the variations in kinetic character

SUBMITTER: Prodanovic M 

PROVIDER: S-EPMC8835009 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature