Conductive Polymer PEDOT:PSS-Based Platform for Embryonic Stem-Cell Differentiation.

ABSTRACT: Organic semiconductors are constantly gaining interest in regenerative medicine. Their tunable physico-chemical properties, including electrical conductivity, are very promising for the control of stem-cell differentiation. However, their use for combined material-based and electrical stimulation remains largely underexplored. Therefore, we carried out a study on whether a platform based on the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) can be beneficial to the differentiation of mouse embryonic stem cells (mESCs). The platform was prepared using the layout of a standard 24-well cell-culture plate. Polyethylene naphthalate foil served as the substrate for the preparation of interdigitated gold electrodes by physical vapor deposition. The PEDOT:PSS

SUBMITTER: Safarikova E 

PROVIDER: S-EPMC8835127 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature