Changes of Gut Microbiota by Natural mtDNA Variant Differences Augment Susceptibility to Metabolic Disease and Ageing.

ABSTRACT: We recently reported on two mouse strains carrying different single nucleotide variations in the mitochondrial complex I gene, i.e., B6-mt^BPL mice carrying m.11902T>C and B6-mt^ALR carrying m.4738C>A. B6-mt^BPL mice exhibited a longer lifespan and a lower metabolic disease susceptibility despite mild mitochondrial functional differences in steady-state. As natural polymorphisms in the mitochondrial DNA (mtDNA) are known to be associated with distinct patterns of gut microbial composition, we further investigated the gut microbiota composition in these mice strains. In line with mouse phenotypes, we found a significantly lower abundance of Proteobacteria, which is positively associated with pathological conditions, in B6-mt^BPL compared to B6-

SUBMITTER: Kunstner A 

PROVIDER: S-EPMC8835372 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature