Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering.

ABSTRACT: Intractable cancers such as osteosarcoma (OS) and oral cancer (OC) are highly refractory, recurrent, and metastatic once developed, and their prognosis is still disappointing. Tumor-targeted therapy, which eliminates cancers effectively and safely, is the current clinical choice. Since aggressive tumors are substantially resistant to multidisciplinary therapies that target apoptosis, tumor-specific activation of another cell death modality is a promising avenue for meeting this goal. Here, we report that a cold atmospheric air plasma-activated medium (APAM) can kill OS and OC by causing a unique mitochondrial clustering. This event was named monopolar perinuclear mitochondrial clustering (MPMC) based on its characteristic unipolar mitochondrial perinuclear accumulation. The APAM caused apo

SUBMITTER: Suzuki-Karasaki M 

PROVIDER: S-EPMC8835529 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature