Association between blood metals mixtures concentrations and cognitive performance, and effect modification by diet in older US adults.

ABSTRACT:

Background

Chronic exposure to heavy metals has been associated with adverse neurological outcomes in older adults. Inflammatory processes are suspected as an underlying pathway by which metals exert their neurotoxicity. In parallel, a diet rich in antioxidant and anti-inflammatory components may protect against chronic inflammation.

Objectives

We examined the associations of blood concentrations of lead, cadmium, and manganese as a mixture with cognitive performance in older US adults and potential modification of these associations by diet as measured by the Healthy Eating Index 2015 (HEI-2015) and the Adapted Dietary Inflammatory Index (ADII).

Methods

We used data on 1,777 adults ≥60 years old from the US National Health and Nutrition Examination Survey (NHANES; 20

SUBMITTER: Laouali N 

PROVIDER: S-EPMC8835643 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature