Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.

ABSTRACT: Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a subject of intensive research. Currently, there are no clinically approved drugs that can act as preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties of a compound-myo-inositol (MI) and the present research broadens previous results and demonstrates the long-term disease-modifying effect of this drug, as well as the amelioration of cognitive comorbidities. For the first time, we show that long-term treatment with MI: (i) decreases the frequency and duration of electrographic SRS in the hippocamp

SUBMITTER: Kandashvili M 

PROVIDER: S-EPMC8835653 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature