Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer.

ABSTRACT: Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physical agents. They are also in charge of the control of the immune response and account for the repair of the damaged tissues, eventually restoring tissue homeostasis. The balance between these dual activities must be thoroughly controlled in space and time. Any sustained unbalanced response of MP leads to pathological disorders, such as chronic inflammation, or favors cancer development and progression. In this review, we take advantage of our expertise in chronic inflammation, especially in rheuma

SUBMITTER: Degboe Y 

PROVIDER: S-EPMC8835955 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature