The Role of Small Extracellular Vesicles in the Progression of Colorectal Cancer and Its Clinical Applications.

ABSTRACT: Colorectal cancer (CRC) is one of the most common cancers worldwide and a longstanding critical challenge for public health. Screening has been suggested to effectively reduce both the incidence and mortality of CRC. However, the drawback of the current screening modalities, both stool-based tests and colonoscopies, is limited screening adherence, which reduces the effectiveness of CRC screening. Blood tests are more acceptable than stool tests or colonoscopy as a first-line screening approach. Therefore, identifying blood biomarkers for detecting CRC and its precancerous neoplasms is urgently needed to fulfill the unmet clinical need. Currently, many kinds of blood contents, such as circulating tumor cells, circulating tumor nucleic acids, and extracellular vesicles, have been investigate

SUBMITTER: Chang LC 

PROVIDER: S-EPMC8835972 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature