Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC8835986 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Li Yutao Y Sharma Amit A Maciaczyk Jarek J Schmidt-Wolf Ingo G H IGH
International journal of molecular sciences 20220124 3
Glioblastoma multiforme (GBM) is an aggressive and dismal disease with a median overall survival of around 15 months and a 5-year survival rate of 7.2%. Owing to genetic mutations, drug resistance, disruption to the blood-brain barrier (BBB)/blood-brain tumor barrier (BBTB), and the complexity of the immunosuppressive environment, the therapeutic approaches to GBM represent still major challenges. Conventional therapies, including surgery, radiotherapy, and standard chemotherapy with temozolomid ...[more]