Genetic and Epigenetic Markers of Lithium Response.

ABSTRACT: The mood stabilizer lithium represents a cornerstone in the long term treatment of bipolar disorder (BD), although with substantial interindividual variability in clinical response. This variability appears to be modulated by genetics, which has been significantly investigated in the last two decades with some promising findings. In addition, recently, the interest in the role of epigenetics has grown significantly, since the exploration of these mechanisms might allow the elucidation of the gene-environment interactions and explanation of missing heritability. In this article, we provide an overview of the most relevant findings regarding the pharmacogenomics and pharmacoepigenomics of lithium response in BD. We describe the most replicated findings among candidate gene studies, results f

SUBMITTER: Pisanu C 

PROVIDER: S-EPMC8836013 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature