An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions.

ABSTRACT: Obesity has become a global epidemic that has a negative impact on population health and the economy of nations. Genetic predispositions have been demonstrated to have a substantial role in the unbalanced energy metabolism seen in obesity. However, these genetic variations cannot entirely explain the massive growth in obesity over the last few decades. Accumulating evidence suggests that modern lifestyle characteristics such as the intake of energy-dense foods, adopting sedentary behavior, or exposure to environmental factors such as industrial endocrine disruptors all contribute to the rising obesity epidemic. Recent advances in the study of DNA and its alterations have considerably increased our understanding of the function of epigenetics in regulating energy metabolism and expenditure

SUBMITTER: Mahmoud AM 

PROVIDER: S-EPMC8836029 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature