C-Reactive Protein as a Biomarker for Major Depressive Disorder?

ABSTRACT: The etiopathogenesis of depression is not entirely understood. Several studies have investigated the role of inflammation in major depressive disorder. The present work aims to review the literature on the association between C-Reactive Protein (CRP) and depression. A systematic review was performed for the topics of 'CRP' and 'depression' using the PubMed database from inception to December 2021. Fifty-six studies were identified and included in the review. Evidence suggested the presence of dysregulation in the inflammation system in individuals with depression. In most studies, higher blood CRP levels were associated with greater symptom severity, a specific pattern of depressive symptoms, and a worse response to treatment. Moreover, about one-third of depressed patients showed a low-gr

SUBMITTER: Orsolini L 

PROVIDER: S-EPMC8836046 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature