Profiling of the Bacterial Microbiota along the Murine Alimentary Tract.

ABSTRACT: Here, the spatial distribution of the bacterial flora along the murine alimentary tract was evaluated using high throughput sequencing in wild-type and Tff3-deficient (Tff3^KO) animals. Loss of Tff3 was linked to increased dextran sodium sulfate-induced colitis. This systematic study shows the results of 13 different regions from the esophagus to the rectum. The number of bacterial species (richness) increased from the esophagus to the rectum, from 50 to 200, respectively. Additionally, the bacterial community structure changed continuously; the highest changes were between the upper/middle and lower gastrointestinal compartments when comparing adjacent regions. Lactobacillus was the major colonizer in the upper/middle gastrointestinal tract, especiall

SUBMITTER: Vilchez-Vargas R 

PROVIDER: S-EPMC8836272 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature