New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

ABSTRACT: Reelin is an extracellular matrix protein that is mainly produced in Cajal-Retzius cells and controls neuronal migration, which is important for the proper formation of cortical layers in the developmental stage of the brain. In the adult brain, Reelin plays a crucial role in the regulation of N-methyl-D-aspartate receptor-dependent synaptic function, and its expression decreases postnatally. Clinical studies showed reductions in Reelin protein and mRNA expression levels in patients with psychiatric disorders; however, the causal relationship remains unclear. Reelin-deficient mice exhibit an abnormal neuronal morphology and behavior, while Reelin supplementation ameliorates learning deficits, synaptic dysfunctions, and spine loss in animal models with Reelin deficiency. These findings sugg

SUBMITTER: Tsuneura Y 

PROVIDER: S-EPMC8836358 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature