Educating EVs to Improve Bone Regeneration: Getting Closer to the Clinic.

ABSTRACT: The incidence of bone-related disorders is continuously growing as the aging of the population in developing countries continues to increase. Although therapeutic interventions for bone regeneration exist, their effectiveness is questioned, especially under certain circumstances, such as critical size defects. This gap of curative options has led to the search for new and more effective therapeutic approaches for bone regeneration; among them, the possibility of using extracellular vesicles (EVs) is gaining ground. EVs are secreted, biocompatible, nano-sized vesicles that play a pivotal role as messengers between donor and target cells, mediated by their specific cargo. Evidence shows that bone-relevant cells secrete osteoanabolic EVs, whose functionality can be further improved by several

SUBMITTER: Infante A 

PROVIDER: S-EPMC8836395 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature