Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.

ABSTRACT: There are several open questions to be answered regarding the pathophysiology of the development of preeclampsia (PE). Numerous factors are involved in its genesis, such as defective placentation, vascular impairment, and an altered immune response. The activation of the adaptive and innate immune system represents an immunologic, particularity during PE. Proinflammatory cytokines are predominantly produced, whereas immune regulatory and immune suppressive factors are diminished in PE. In the present study, we focused on the recruitment of regulatory T cells (Tregs) which are key players in processes mediating immune tolerance. To identify Tregs in the decidua, an immunohistochemical staining of FoxP3 of 32 PE and 34 control placentas was performed. A clearly reduced number of FoxP3-positi

SUBMITTER: Meister S 

PROVIDER: S-EPMC8836599 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature